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SH-6

Akt inhibitor
 
ALX-270-350-MC05 0.5 mg 155.00 USD
 
ALX-270-350-M001 1 mg 276.00 USD
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Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

Product Specification

Alternative Name:D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
 
Formula:C28H57O9P
 
MW:568.7
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR, 13C-NMR, 31P-NMR, and LC-MS.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-350
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270-350

Product Literature References

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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