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SH-5

Akt inhibitor
 
ALX-270-349-MC05 0.5 mg 155.00 USD
 
ALX-270-349-M001 1 mg 263.00 USD
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Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

Product Specification

Alternative Name:D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
 
Formula:C29H59O10P
 
MW:598.7
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR, 31P-NMR, 13C-NMR and MS.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-349
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270-349

Product Literature References

Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia: B. Zhu, et al.; Int. J. Clin. Exp. Pathol. 8, 12595 (2015), Application(s): Cell culture, Abstract; Full Text
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003), Abstract;

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