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United States 

LY-333,531 . hydrochloride

PKCβ inhibitor
 
ALX-270-348-M001 1 mg 96.00 USD
 
ALX-270-348-M005 5 mg 378.00 USD
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Isozyme selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC50=4.7nM) and PKCβII (IC50=5.9nM) isozymes. 76- and 61-fold more selective for inhibition of PKCβI and PKCβII over PKCα.Not offered in the US.

Product Specification

Alternative Name:(S)-13-[(Dimethylamino)methyl-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H-13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)dione . HCl, Ruboxistaurin . hydrochloride
 
Formula:C28H28N4O3 . HCl
 
MW:468.6 . 36.5
 
CAS:169939-93-9
 
MI:14: 8290
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Red solid.
 
Solubility:Soluble in DMSO; slightly soluble in 100% ethanol or water.
 
Shipping:Ambient
 
Long Term Storage:-80°C
 
Handling:Protect from light
 
270-348
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270-348

Product Literature References

Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2.: H. Soliman, et al.; Am. J. Physiol. Heart Circ. Physiol. 303, H989 (2012), Abstract; Full Text
Ruboxistaurin: LY 333531: Drugs R. D. 8, 193 (2007), (Review), Abstract;
Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats: Y. Wu, et al.; J. Pharmacol. Sci. 101, 335 (2006), Abstract; Full Text
Ruboxistaurin: C.A. Taulien & S.V. Joy; Drugs Today (Barc) 42, 577 (2006), Abstract;
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation: S. Itoh, et al.; J. Biol. Chem. 280, 24135 (2005), Abstract; Full Text
Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons: H. Kim, et al.; Diabetes 52, 2102 (2003), Abstract; Full Text
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes: M.A. Cotter, et al.; Clin Sci (Lond) 103, 311 (2002), Abstract;
Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells: Y. Yasuda, et al; BBRC 281, 71 (2001), Abstract;
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase : M.R. Jirousek, et al.; J. Med. Chem. 39, 2664 (1996), Abstract;

General Literature References

Protein kinase C and the development of diabetic vascular complications: K.J. Way, et al.; Diabet. Med. 18, 945 (2001), Review, Abstract;

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