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Ratjadone A (synthetic)

 
ALX-270-346-C002 2 µg 187.00 USD
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Represents a class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC50=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.

Product Specification

Formula:C28H40O5
 
MW:456.6
 
Source:Synthetic.
 
CAS:163564-92-9
 
Formulation:Solution in methanol.
 
Purity:≥95% (HPLC)
 
Identity:Determined by MS, 1H- and 13C-NMR.
 
Appearance:Clear liquid.
 
Solubility:Soluble in methanol (20mg/ml) or aqueous buffers (<100µM).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Sensitive to acids and bases. Unstable in acidic buffer systems (pH<6). Stable in substance as oil and in solution in methanol at -20°C.
 
Handling:Protect from light.
 
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Product Literature References

Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export: S. Strunze, et al.; Mol. Biol. Cell 16, 2999 (2005), Abstract;
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms: T. Meissner, et al.; FEBS Lett. 576, 27 (2004), Abstract;
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 2002, 981 (2002), Abstract;
The chemistry and biology of ratjadone: M. Kalesse, et al.; ChemBioChem. 9, 709 (2001), Abstract;
Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995),
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physio-chemical and biological properties: J. Gerth, et al.; J. Antibiot. 48, 973 (1995), Abstract;

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Leptomycin B 

Nuclear export inhibitor
87081-35-4, Isolated from Streptomyces sp., ≥96% (HPLC) | Print as PDF
 
ALX-380-100-C100 100 µg 142.00 USD
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For Research Use Only. Not for use in diagnostic procedures.
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