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MAZ51

VEGFR-3 inhibitor
 
ALX-270-342-M002 2 mg 105.00 USD
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Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC50=1µM).

Product Specification

Alternative Name:3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one
 
Formula:C21H18N2O
 
MW:314.4
 
CAS:163655-37-6
 
Purity:≥98%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:Orange crystals.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light. Keep under inert gas.
 
270-342
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270-342

Product Literature References

Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells: C.I. Lin, et al.; Cell. Mol. Life Sci. 65, 2740 (2008), Application(s): tube formation and lymphatic marker expression studies on HUVECs, Abstract;
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo: V. Kirkin, et al.; Int. J. Cancer 112, 986 (2004), Application(s): proliferation assays in vivo and on primary human and tumor cell lines, Abstract; Full Text
Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2: V. Kirkin, et al.; Eur. J. Biochem. 268, 5530 (2001), Abstract;

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