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SU 4984

EGFR inhibitor
 
ALX-270-330-M001 1 mg 90.00 USD
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Inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1). Inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50=20-4µM) and the tyrosine phosphorylation of the PDGF receptor and the insulin receptor. Does not inhibit the kinase activity of the EGF receptor.

Product Specification

Alternative Name:3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone
 
Formula:C20H19N3O2
 
MW:333.4
 
CAS:186610-89-9
 
Purity:≥98% (HPLC)
 
Appearance:Orange to red crystalline solid.
 
Solubility:Soluble in DMSO or acetone.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-330
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270-330

Product Literature References

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors: M. Mohammadi, et al.; Science 276, 955 (1997), Abstract;

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