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SB220025

p38 inhibitor
 
ALX-270-325-C500 500 µg 240.00 USD
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Potent and specific inhibitor of human p38 (SAPK2a; IC50=60nM). Exhibits over 2000-fold greater selectivity for p38 over ERK (MAPK), 500-fold over cAMP-dependent protein kinase (PKA), 50-fold over protein kinase C (PKC), and >1000-fold over EGFR. Acts as a potent inhibitor of angiogenesis and as an inhibitor of TNF-α production.

Product Specification

Alternative Name:5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole
 
Formula:C18H19FN6
 
MW:338.4
 
CAS:165806-53-1
 
Purity:≥95% (HPLC)
 
Appearance:White to pale amber solid.
 
Solubility:Soluble in DMSO (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas. Hygroscopic.
 
270-325
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270-325

Product Literature References

Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2: K.H. Kim, et al.; Free Radic. Biol. Med. 65, 1134 (2013), Application(s): PCR, WB, ChIP Assay, Abstract; Full Text
Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway: B. Bellei, et al.; PloS One 7, e330201 (2012), Application(s): WB, PCR, Flow, IF, Abstract; Full Text
Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification: M. Clements, et al.; Curr. Biol. 21, 1289 (2011), Application(s): p38 in regulating the threshold of Nodal signaling and propose a new mechanism by which A-P axis development can be reinforced during early embryogenesis, Abstract; Full Text
TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes: M.P. Sepulcre, et al.; Mol. Immunol. 48, 846 (2011), Application(s): IF, Flow, WB, Abstract;
Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells: W. Zhong, et al.; Reproduction 140, 921 (2010), Application(s): IC, WB, Abstract; Full Text
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models: J.R. Jackson, et al.; J. Pharmacol. Exp. Ther. 284, 687 (1998), Abstract;
Structural basis of inhibitor selectivity in MAP kinases: Z. Wang, et al.; Structure 6, 1117 (1998), Abstract;

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