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Raf1 Kinase Inhibitor I

 
ALX-270-324-M001 1 mg 249.00 USD
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Potent Raf1 kinase inhibitor (IC50=9nM). Shows ≥100-fold selectivity for Raf kinase versus CDK1, CDK2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.

Product Specification

Alternative Name:5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
 
Formula:C15H8Br2INO2
 
MW:520.9
 
CAS:220904-83-6
 
Purity:≥97% (HPLC)
 
Appearance:Off-white to orange powder.
 
Solubility:Soluble in DMSO (200mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for at least 6 months when stored at -20°C.
 
Handling:Protect from light. Keep under inert gas.
 
270-324
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270-324

Product Literature References

The discovery of potent cRaf1 kinase inhibitors: K. Lackey, et al.; Bioorg. Med. Chem. Lett. 10, 223 (2000), Abstract;

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