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CL-387,785

EGFR inhibitor
 
ALX-270-314-M001 1 mg 156.00 USD
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Irreversibly inhibits EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50=250-490pM) and blocks EGF-mediated growth.

Product Specification

Alternative Name:EKI-785, N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
 
Formula:C18H13BrN4O
 
MW:381.2
 
CAS:194423-06-8
 
Purity:≥95% (HPLC)
 
Appearance:Off-white to yellow solid.
 
Solubility:Soluble in DMSO (200mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas. Hygroscopic.
 
270-314
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270-314

Product Literature References

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785): C.M. Discafani, et al.; Biochem. Pharmacol. 57, 917 (1999), Abstract;

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