Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Sirtinol

SIRT inhibitor
 
ALX-270-308-M001 1 mg 34.00 USD
 
ALX-270-308-M005 5 mg 112.00 USD
Do you need bulk/larger quantities?
 
Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM; hSIRT1: IC50=60µM; hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC50=70µM) and hSIRT2 (IC50=40µM) in vitro.

Product Specification

Alternative Name:Sir Two Inhibitor Naphthol, 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
 
Formula:C26H22N2O2
 
MW:394.5
 
CAS:410536-97-9
 
Purity:≥97% (HPLC)
 
Identity:NMR
 
Appearance:Off-white to yellow crystals.
 
Solubility:Soluble in DMSO, 100% ethanol or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Relatively unstable in aqueous solution, especially at acidic pH.
 
Handling:Protect from moisture. Protect from light. Store under inert gas.
 
270-308
Please mouse over
270-308

Product Literature References

Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies: K. Nakai, et al.; Am. J. Pathol. 181, 969 (2012), Abstract;
Identification and characterization of novel sirtuin inhibitor scaffolds: B.D. Sanders, et al.; Bioorg. Med. Chem. 17, 7031 (2009), Abstract;
SIRT1 regulation of apoptosis of human chondrocytes: K. Takayama, et al.; Arthritis Rheum. 60, 2731 (2009), Abstract; Full Text
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006), Abstract;
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005), Abstract;
Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases: B. Heltweg, et al.; Anal. Biochem. 319, 42 (2003), Abstract;
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity: C.E. Koering, et al.; EMBO Rep. 3, 1055 (2002), Abstract; Full Text
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001), Abstract; Full Text

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
SIRT
By biological activity:
SIRT Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Stem Cells
Stem Cells
Download as PDF

Brochures
Epigenetics
Epigenetics
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,