Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Pifithrin-α (cyclic) . hydrobromide

p53 inhibitor
 
ALX-270-287-M010 10 mg 163.00 USD
 
ALX-270-287-M050 50 mg 672.00 USD
Do you need bulk/larger quantities?
 
Stable analog of pifithrin-α (Prod. No. BML-GR325), with biological properties similar to its parent compound, but with reduced cytotoxicity. Inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Potent STAT6 transcriptional inhibitor. Increases apoptosis in target cells when used in combination with antimicrotubule agents.

Product Specification

Formula:C16H16N2S . HBr
 
MW:268.4 . 80.9
 
CAS:60477-34-1
 
Purity:≥95% (HPLC, TLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture. Keep under inert gas.
 
ALX-270-287
Please mouse over
ALX-270-287

Product Literature References

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J Biol Chem 279, 30195 (2004), Abstract;
Suppression of p53: a new approach to overcome side effects of antitumor therapy: E.A. Komarova, et al.; Biochemistry 65, 41 (2000), Abstract; Full Text
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999), Abstract;
Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999), Abstract;

Related Products

Pifithrin-α 

p53 inhibitor
63208-82-2, ≥98% (TLC) | Print as PDF
 
BML-GR325-0005 5 mg 75.00 USD
 
BML-GR325-0025 25 mg 317.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
p53
By biological activity:
p53 Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Stem Cells
Stem Cells
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,