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4-Hydroxyquinazoline

PARP-1 inhibitor
 
ALX-270-279-G001 1 g 30.00 USD
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Replaces Prod. #: BML-AP103

Potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=9.5μM). Attenuates activation of ERK and p38 MAP kinase induced by LPS. Displays beneficial effects in LPS-induced endotoxic shock. Protects the heart from oxidative damage during reperfusion injury.

Product Specification

Alternative Name:4-HQN, 4-Quinazolinol
 
Formula:C8H6N2O
 
MW:146.2
 
CAS:491-36-1
 
RTECS:VA2300000
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (50mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-279
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270-279

Product Literature References

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract;
Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice: B. Veres, et al.; J. Pharmacol. Exp. Ther. 310, 247 (2004), Abstract;
Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system: R. Halmosi, et al.; Mol. Pharmacol. 59, 1497 (2001), Abstract;
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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