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Trolox®

Cell permeable vitamin E derivative
 
ALX-270-267-M100 100 mg 34.00 USD
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Replaces Prod. #: BML-FR105

Cell permeable derivative of vitamin E. Antioxidant. Inhibits peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Prevents lipid peroxidation, cytotoxicity and apoptosis induced by cytochrome P450 2E1 in HEP G2 cells.

Product Specification

Alternative Name:6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
 
Formula:C14H18O4
 
MW:250.3
 
CAS:53188-07-1; 56305-04-5
 
RTECS:DJ2273000
 
Purity:≥96.5% (Titration (T) NaOH 0.1M)
 
Identity:Determined by IR.
 
Appearance:White to off-white, pale yellow or pale green powder.
 
Solubility:Soluble in 100% ethanol (25mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-270-267
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ALX-270-267

Product Literature References

Bactericidal activity of green tea extracts: the importance of catechin containing nano particles: J. Gopal, et al.; Sci. Rep. 6, 19710 (2016), Application(s): Cell culture, Abstract; Full Text
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer: J.L. Roh, et al.; Cancer Lett. 381, 96 (2016), Application(s): Cell viability assays, Abstract;
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells: Q. Chen et al.; Mol. Pharmacol. 53, 638 (1998), Abstract;
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells: Q. Chen et al.; Mol. Pharmacol. 53, 638 (1998), Abstract;
Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?: A.S. Pannala et al.; Free Radic Biol Med 24, 594 (1998), Abstract;
Peroxynitrite and brain mitochondria: evidence for increased proton leak: P.S. Brookes et al.; J. Neurochem. 70, 2195 (1998), Abstract;
Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes: M.G. Salgo & W.A. Pryor; Arch. Biochem. Biophys. 333, 482 (1996), Abstract;
Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected]: M.G. Salgo, et al.; Arch. Biochem. Biophys. 322, 500 (1995), Abstract;

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