Aminopurvalanol A

CDK/cyclin inhibitor



ALX-270-249-M001	1 mg	47.00 USD

ALX-270-249-M005	5 mg	140.00 USD

Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC₅₀=33nM), CDK2/cyclin A (IC₅₀=33nM), CDK2/cyclin E (IC₅₀=28nM) and CDK5/p35 (IC₅₀=20nM).

Product Specification

Alternative Name:	(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97

Formula:	C₁₉H₂₆N₇OCl

MW:	403.9

Purity:	≥97% (¹H-NMR)

Appearance:	White to brownish solid.

CAS:	220792-57-4

Solubility:	Soluble in DMSO or methanol.

Long Term Storage:	+4°C

Hazard:	IRRITANT.

Handling:	Packaged under inert gas. Protect from light.

Please mouse over

Product Literature References

M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol: M. Le Breton, et al.; BBRC 306, 880 (2003), Abstract;

A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts: G.R. Rosania, et al.; PNAS 96, 4797 (1999), Abstract; Full Text

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors: Y.T. Chang, et al.; Chem. Biol. 6, 361 (1999), Abstract;