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Purvalanol A

CDK/cyclin inhibitor
 
ALX-270-246-M001 1 mg 62.00 USD
 
ALX-270-246-M005 5 mg 264.00 USD
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Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.

Product Specification

Alternative Name:6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
 
Formula:C19H25N6OCl
 
MW:388.9
 
CAS:212844-53-6
 
Purity:≥99% (NMR)
 
Appearance:Off-white to yellow powder.
 
Solubility:Soluble in DMSO, methanol or dichloromethane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Keep under inert gas. Keep cool and dry.
 
270-246
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270-246

Product Literature References

Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One 8, e72886 (2013), Abstract; Full Text
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004), Abstract;
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis: P. Chadebech, et al.; Int. J. Cancer 87, 779 (2000), Abstract;
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science 281, 533 (1998), Abstract;

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