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AM 281

CB1 receptor ligand
 
ALX-270-240-M001 1 mg 30.00 USD
 
ALX-270-240-M005 5 mg 73.00 USD
 
ALX-270-240-M025 25 mg 290.00 USD
Do you need bulk/larger quantities?
 
Analog of the cannabinoid receptor (CB) antagonist SR 141716A. Potent CB1 receptor antagonist/inverse agonist (Ki=14nM).

Product Specification

Alternative Name:1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
 
Formula:C21H19Cl2IN4O2
 
MW:557.2
 
CAS:202463-68-1
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by 1H-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in methanol (1mg/ml) or DMSO (2mg/ml at RT, 50mg/ml in hot DMSO, after cooling this solution is stable over several days.)
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-270-240
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ALX-270-240

Product Literature References

Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats: Y. Kadoi, et al.; Crit. Care Med. 33, 2629 (2005), Abstract;
Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats: Y. Kadoi, et al.; Br. J. Anaesth. 94, 563 (2005), Abstract;
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats: N.A. Werner, et al.; Brain Res. 967, 290 (2003), Abstract;
Large receptor reserve for cannabinoid actions in the central nervous system: A. N. Gifford, et al.; J. Pharmacol. Exp. Ther. 288, 478 (1999), Abstract;
Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo: S.J. Gatley, et al.; J. Neurochem. 70, 417 (1998), Abstract;
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices: A.N. Gifford, et al.; Neurosci. Lett. 238, 84 (1997), Abstract;

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