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PD 150,606

Calpain inhibitor
 
ALX-270-234-M005 5 mg 80.00 USD
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Cell permeable, selective, and non-peptide calpain inhibitor directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases such as cathepsin B and cathepsin L. Prevents dexamethasone-induced apoptosis in thymocytes. Calpain I (Ki=210nM), Calpain II (Ki=370nM)

Product Specification

Formula:C9H7IO2S
 
MW:306.1
 
CAS:426821-41-2
 
Purity:≥95% (NMR)
 
Appearance:White to light yellow solid.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Keep under inert gas.
 
ALX-270-234
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ALX-270-234

Product Literature References

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death: K. Moriwaki, et al.; Cell Death Dis. 6, e1636 (2015), Application(s): Cell Culture, Abstract; Full Text
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003), Abstract;
Calpains mediate calcium and chloride influx during the late phase of cell injury: S.L. Waters, et al.; J. Pharmacol. Exp. Ther. 283, 1177 (1997), Abstract;
Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997), Abstract;
Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996), Abstract;
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996), Abstract;
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996), Abstract;

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