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NS-2028

Guanylyl cyclase inhibitor
 
ALX-270-210-M001 1 mg 41.00 USD
 
ALX-270-210-M005 5 mg 133.00 USD
 
ALX-270-210-M025 25 mg 390.00 USD
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Replaces Prod. #: BML-CN222

A potent and selective, cell-permeable inhibitor of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC). Inhibition is irreversible. Inhibits also the basal, the YC-1 and the coenhanced sGC activity. Complete inhibition of NO-induced relaxation in vascular and nonvascular smooth muscle at 1μM.

Product Specification

Alternative Name:4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
 
Formula:C9H5BrN2O3
 
MW:269.1
 
CAS:204326-43-2
 
Purity:≥98% (TLC)
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in DMSO or 100% ethanol; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from moisture.
 
270-210
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270-210

Product Literature References

Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase: I. Fleming, et al.; PNAS 96, 1123 (1999), Abstract;
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production: L. Bang, et al.; Scand. Cardiovasc. J. 33, 33 (1999), Abstract;
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase: S.P. Olesen, et al.; Br. J. Pharmacol. 123, 299 (1998), Abstract;

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