J-8 . hydrochloride

Calmodulin antagonist. PDE inhibitor.



ALX-270-208-M005	5 mg	23.00 USD

ALX-270-208-M025	25 mg	91.00 USD

Highly selective calmodulin (CaM) antagonist. Inhibitor of Ca²⁺/calmodulin-dependent phosphodiesterase. Has a selectivity of ~300-fold over Ca²⁺/CaM-dependent enzymes compared with Ca²⁺-dependent but CaM-independent enzymes, e.g. protein kinase C (PKC) and transglutaminase.

Product Specification

Alternative Name:	(N-8-Aminooctyl)-5-iodo-1-naphthalenesulfonamide . HCl

Formula:	C₁₈H₂₅IN₂O₂S . HCl

MW:	460.4 . 36.5

Appearance:	Off-white powder.

CAS:	187937-24-2

Solubility:	Soluble in DMSO; slightly soluble in 100% ethanol.

Long Term Storage:	-20°C

Handling:	Hygroscopic .

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Product Literature References

Complexes formed between calmodulin and the antagonists J-8 and TFP in solution: C.J. Craven, et al.; Biochemistry 35, 10287 (1996), Abstract;

Calmodulin antagonists of improved potency and specificity for use in the study of calmodulin biochemistry: S. MacNeil, et al.; Biochem. Pharmacol. 37, 1717 (1988), Abstract;