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N-ω-Propyl-L-arginine

nNOS inhibitor
 
ALX-270-203-M005 5 mg 80.00 USD
 
ALX-270-203-M025 25 mg 194.00 USD
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Potent and selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (3158-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (149-fold).

Product Specification

Alternative Name:N5-[Imino(propylamino)methyl]-L-ornithine
 
Formula:C9H20N4O2
 
MW:216.3
 
CAS:137361-05-8
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in PBS, pH 7.2 (25mg/ml), 100% ethanol (10mg/ml), DMSO (50μg/ml) or dimethyl formamide (50μg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least one year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
 
ALX-270-203
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ALX-270-203

Product Literature References

The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle: C. Gowda, et al.; Nitric Oxide 11, 17 (2004), Abstract;
The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice: D. Klamer, et al.; Eur. J. Pharmacol. 503, 103 (2004), Abstract;
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003), Abstract; Full Text
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003), Abstract; Full Text
Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform: G.R. Cooper, et al.; Arch. Biochem. Biophys. 375, 183 (2000), Abstract;
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract; Full Text
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases: Y. Lee, et al.; Bioorg. Med. Chem. 7, 1097 (1999), Abstract;
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase: H. Huang, et al.; J. Med. Chem. 42, 3147 (1999), Abstract;
Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine: H.Q. Zhang, et al.; JACS 119, 10888 (1997),
Potent and selective inhibition of neuronal nitric oxide synthase by N-omega-propyl-L-arginine: H.Q. Zhang, et al.; J. Med. Chem. 40, 3869 (1997), Abstract;

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