Replaces Prod. #: BML-EI271
Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor (IC50~10 µM). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of FcεR1-mediated signaling. Activator of human deacetylase SIRT1.
Product Details
| Alternative Name: | 3,4,3',5'-Tetrahydroxy-trans-stilbene |
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| Formula: | C14H12O4 |
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| MW: | 244.2 |
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| Source: | Synthetic. |
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| CAS: | 10083-24-6 |
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| Purity: | ≥98% (HPLC (UV)) |
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| Appearance: | Off-white to light pink crystalline solid. |
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| Solubility: | Soluble in DMSO (>50mg/ml), methanol (>50mg/ml), dioxan (>50mg/ml), acetonitrile (>50mg/ml); slightly soluble in water (1mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Unstable in sodium hydroxide. |
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| Handling: | Protect from light and oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One
14, e0210607 (2019),
Abstract;
Full Text
Gαs proteins Activate p72 Syk and p60-c-Src Tyrosine Kinases to Mediate Sickle Red Blood Cell Adhesion to Endothelium via LW-αvβ3 and CD44-CD44 Interactions: E. Chiou, et al.; Int. J. Biochem. Cell. Biol.
65, 40 (2015),
Application(s): Cell Culture,
Abstract;
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature
425, 191 (2003),
Abstract;
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells : D. Jeoung, et al.; Biotechnology Lett.
24, 463 (2002),
Abstract;
Full Text
Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro: C.J. Seow, et al.; Eur. J. Pharmacol.
443, 189 (2002),
Abstract;
FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells: C .Tkaczyk, et al.; Immunology
97, 333 (1999),
Abstract;
Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex: J. Zheng & V.D. Ramirez; BBRC
261, 499 (1999),
Abstract;
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells: B. Cambien, et al.; J. Immunol.
163, 5079 (1999),
Abstract;
Full Text
Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase: J.M. Muller, et al.; Am. J. Physiol.
270, H1878 (1996),
Abstract;
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine: J.D. Peters, et al.; J. Biol. Chem.
271, 4755 (1996),
Abstract;
Full Text
Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases: I. Fleming, et al.; Circul. Res.
76, 522 (1995),
Abstract;
The tyrosine phosphorylation of a p72syk-like protein in activated murine resident peritoneal macrophages: K.I. Abu-Lawi & B.M. Sultzer; Cell Mol. Biol. Res.
41, 49 (1995),
Abstract;
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol: J.M. Oliver, et al.; J. Biol. Chem.
269, 29697 (1994),
Abstract;
Full Text
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization: M. Cushman, et al.; J. Med. Chem.
34, 2579 (1991),
Abstract;
General Literature References
Effect of tyrosine kinase inhibitors on luteinizing hormone-releasing hormone (LHRH)-induced gonadotropin release from the anterior pituitary: M.S. Johnson, et al.; Mol. Cell Endocrinol.
109, 69 (1995),
Abstract;
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor: R.L. Geahlen, et al.; Biochem. Biophys. Res. Commun.
165, 241 (1989),
Abstract;
