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Piceatannol

Syk inhibitor. SIRT1 activator.
 
ALX-270-202-M001 1 mg 38.00 USD
 
ALX-270-202-M005 5 mg 66.00 USD
 
ALX-270-202-M010 10 mg 116.00 USD
 
ALX-270-202-M050 50 mg 432.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-EI271

Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor (IC50~10 µM). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of FcεR1-mediated signaling. Activator of human deacetylase SIRT1.

Product Specification

Alternative Name:3,4,3',5'-Tetrahydroxy-trans-stilbene
 
Formula:C14H12O4
 
MW:244.2
 
Source:Synthetic.
 
CAS:10083-24-6
 
Purity:≥98% (HPLC (UV))
 
Appearance:Off-white to light pink crystalline solid.
 
Solubility:Soluble in DMSO (>50mg/ml), methanol (>50mg/ml), dioxan (>50mg/ml), acetonitrile (>50mg/ml); slightly soluble in water (1mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Unstable in sodium hydroxide.
 
Handling:Protect from light and oxygen.
 
ALX-270-202
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ALX-270-202

Product Literature References

Gαs proteins Activate p72 Syk and p60-c-Src Tyrosine Kinases to Mediate Sickle Red Blood Cell Adhesion to Endothelium via LW-αvβ3 and CD44-CD44 Interactions: E. Chiou, et al.; Int. J. Biochem. Cell. Biol. 65, 40 (2015), Application(s): Cell Culture, Abstract;
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003), Abstract;
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells : D. Jeoung, et al.; Biotechnology Lett. 24, 463 (2002), Abstract; Full Text
Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro: C.J. Seow, et al.; Eur. J. Pharmacol. 443, 189 (2002), Abstract;
FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells: C .Tkaczyk, et al.; Immunology 97, 333 (1999), Abstract;
Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex: J. Zheng & V.D. Ramirez; BBRC 261, 499 (1999), Abstract;
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells: B. Cambien, et al.; J. Immunol. 163, 5079 (1999), Abstract; Full Text
Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase: J.M. Muller, et al.; Am. J. Physiol. 270, H1878 (1996), Abstract;
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine: J.D. Peters, et al.; J. Biol. Chem. 271, 4755 (1996), Abstract; Full Text
Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases: I. Fleming, et al.; Circul. Res. 76, 522 (1995), Abstract;
The tyrosine phosphorylation of a p72syk-like protein in activated murine resident peritoneal macrophages: K.I. Abu-Lawi & B.M. Sultzer; Cell Mol. Biol. Res. 41, 49 (1995), Abstract;
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol: J.M. Oliver, et al.; J. Biol. Chem. 269, 29697 (1994), Abstract; Full Text
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization: M. Cushman, et al.; J. Med. Chem. 34, 2579 (1991), Abstract;

General Literature References

Effect of tyrosine kinase inhibitors on luteinizing hormone-releasing hormone (LHRH)-induced gonadotropin release from the anterior pituitary: M.S. Johnson, et al.; Mol. Cell Endocrinol. 109, 69 (1995), Abstract;
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor: R.L. Geahlen, et al.; Biochem. Biophys. Res. Commun. 165, 241 (1989), Abstract;

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