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3-Bromo-7-nitroindazole . sodium salt

nNOS inhibitor
ALX-270-199-M025 25 mg 65.00 USD
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Salt form of 3-bromo-7-nitroindazole (Prod. No. ALX-270-009). Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole (Prod. No. ALX-270-004).

Product Specification

Formula:C7H3BrN3O2 . Na
MW:241.0 . 23.0
CAS:74209-34-0 (non-salt)
Purity:≥97% (TLC)
Appearance:Red solid.
Solubility:Soluble in DMSO or methanol; insoluble in water.
Long Term Storage:-20°C
Handling:Hygroscopic. Protect from light.
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Product Literature References

Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56 (2006), Abstract;
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry 40, 13448 (2001), Abstract;
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res. 870, 80 (2000), Abstract;
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience 78, 393 (1997), Abstract;
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol. 324, 11 (1997), Abstract;
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci. 57, PL131 (1995), Abstract;

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