Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).
Product Details
| Alternative Name: | PMSF, Benzylsulfonyl fluoride |
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| Formula: | C7H7FO2S |
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| MW: | 174.2 |
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| CAS: | 329-98-6 |
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| RTECS: | XT8040000 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white needle crystals. |
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| Solubility: | Soluble in 100% ethanol, methanol or isopropanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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