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S-Ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea . hydrochloride

nNOS inhibitor
 
ALX-270-182-M005 5 mg 30.00 USD
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Selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (115-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (29-fold).

Product Specification

Alternative Name:ETPI . HCl, TFPI . HCl, SEPIT . HCl, ETU
 
Formula:C10H11SN2F3 . HCl
 
MW:248.3 . 36.5
 
CAS:163490-78-6
 
Purity:≥98%
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (50mg/ml), methanol, 100% ethanol (33mg/ml), DMSO (33mg/ml) or dimethyl formamide (33mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-270-182
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ALX-270-182

Product Literature References

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase: T. Castano, et al.; Bioorg. Med. Chem. 16, 6193 (2008), Abstract;
Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS: S. Philipp, et al.; Am. J. Physiol. Heart Circ. Physiol. 290, H450 (2006), Abstract; Full Text
Cardioprotection during the final stage of the late phase of ischemic preconditioning is mediated by neuronal NO synthase in concert with cyclooxygenase-2: Y. Wang, et al.; Circ. Res. 95, 84 (2004), Abstract; Full Text
Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform: G.R. Cooper, et al.; Arch. Biochem. Biophys. 375, 183 (2000), Abstract;
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity: B.G. Shearer, et al.; J. Med. Chem. 40, 1901 (1997), Abstract;

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