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Chlorpromazine . hydrochloride

Antipsychotic working on a variety of receptors in the CNS
 
ALX-270-171-G005 5 g 53.00 USD
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Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.

Product Specification

Alternative Name:2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
 
Formula:C17H19ClN2S . HCl
 
MW:355.3
 
CAS:69-09-0
 
MI:14: 2185
 
RTECS:SO1750000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol, methanol or water (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
 
Handling:Protect from light.
 
ALX-270-171
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ALX-270-171

Product Literature References

Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004), Abstract;
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002), Abstract;
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995), Abstract;
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993), Abstract;
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993), Abstract;
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993), Abstract;
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985), Abstract;
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974), Abstract;

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