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Furegrelate sodium

Thromboxane A2 synthase inhibitor
ALX-270-120-M050 50 mg 398.00 USD
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Replaces Prod. #: BML-EI111

Potent and selective orally active inhibitor of thromboxane A2 synthase (ED50=10ng/ml, human platelets).

Product Specification

Alternative Name:U-63557A, Sodium furegrelate
Formula:C15H10NO3 . Na
MW:252.2 . 23.0
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:White to off-white crystalline solid.
Solubility:Soluble in water (15mg/ml), methanol or DMSO.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year when stored at -20°C. Before use, prepare a stock solution by dissolving the product in water. Stock solutions will be stable for at least 1 month if stored at 0°C in an oxygen-free environment.
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Product Literature References

Angiotensin II constriction of rat vasa recta is partially thromboxane dependent: E.P. Silldorff, et al.; Hypertension 40, 541 (2002), Abstract;
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects: J.S. Mohrland, et al.; Eur. J. Clin. Pharmacol. 38, 485 (1990), Abstract;
Pharmacokinetics of furegrelate after oral administration to normal humans: D.B. Lakings, et al.; Pharm. Res. 6, 53 (1989), Abstract;
Thromboxane synthase activity and platelet function after furegrelate administration in man: J.S. Mohrland, et al.; J. Clin. Pharmacol. 29, 53 (1989), Abstract;
A.M. Lefer; Drugs Future 11, 197 (1986),
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids: R.A. Johnson, et al.; J. Med. Chem. 29, 1461 (1986), Abstract;
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate: R.R. Gorman, et al.; Prostaglandins 26, 325 (1983), Abstract;

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