Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


Organoselenium compound. Antioxidant.
ALX-270-097-M005 5 mg 37.00 USD
ALX-270-097-M025 25 mg 75.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-EI207

Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL). Protects cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.

Product Specification

Purity:≥98% (HPLC)
Identity:Determined by NMR.
Appearance:White to off-white crystalline solid.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20°C
Handling:Protect from light.
Please mouse over

Product Literature References

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2: J.D. Bernstock, et al.; FASEB J. 32, 1677 (2018), Abstract;
Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers: L. Zuo, et al.; J. Appl. Physiol. 111, 898 (2011), Abstract; Full Text
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998), Abstract; Full Text
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998), Abstract;
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997), Abstract;
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997), Abstract;
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995), Abstract;
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995), Abstract;
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994), Abstract;
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994), Abstract;
Interaction of ebselen with glutathione S-transferase and papain in vitro: T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994), Abstract;
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994), Abstract;
Action of ebselen as an antioxidant against lipid peroxidation:: N. Noguchi, et al.; Biochem. Pharmacol. 44, 39 (1992), Abstract;
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989), Abstract;
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988), Abstract;
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987), Abstract;
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984), Abstract;

General Literature References

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer: B. Kasraee, et al.; Exp. Dermatol. 21, 19 (2012), Abstract;

Related Literature

Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Technical Posters
Arachidonic Acid Metabolites
Arachidonic Acid Metabolites
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,