Indomethacin

COX-1 inhibitor. PPAR activator.



ALX-270-086-G001	1 g	23.00 USD

ALX-270-086-G005	5 g	29.00 USD

ALX-270-086-G025	25 g	83.00 USD

Replaces Prod. #: BML-EI131

Non-steroidal anti-inflammatory and analgesic agent. Inhibits cyclooxygenase (IC₅₀=0.1µM) selectively over lipoxygenases (IC₅₀=100µM for 5-, 12- and 15-LO). Preferentially inhibits PGH synthase-1 over PGH synthase-2 (ID₅₀=4.9-8.1 and 130-160µM respectively). Activates PPARα and γ receptors and induces adipocyte differentiation (EC₅₀=8µM). A clinically useful NSAID.

Product Specification

Formula:	C₁₉H₁₆ClNO₄

MW:	357.8

Purity:	≥98%

Appearance:	Off-white solid.

CAS:	53-86-1

MI:	14: 4968

Solubility:	Soluble in acetone or methanol; insoluble in water.

Long Term Storage:	+20°C

Hazard:	VERY TOXIC.

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Product Literature References

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs: J.M. Lehmann, et al.; J. Biol. Chem. 272, 3406 (1997), Abstract;

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994), Abstract;

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem. 268, 6610 (1993), Abstract;

Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992), Abstract;

Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984), Abstract;

Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977), Abstract;