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Milrinone

PDE3 inhibitor
 
ALX-270-083-M005 5 mg 106.00 USD
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Replaces Prod. #: BML-PD152

Selective inhibitor of phosphodiesterase 3 (PDE3, IC50=0.3µM).

Product Specification

Alternative Name:1,6-Dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile
 
Formula:C12H9N3O
 
MW:211.2
 
CAS:78415-72-2
 
MI:14: 6197
 
RTECS:DW1762000
 
Purity:≥97% (Total Nitrogen)
 
Identity:Determined by IR and NMR.
 
Appearance:White to light red solid.
 
Solubility:Soluble in DMSO (20mg/ml) or warm 100% ethanol (3mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-083
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270-083

Product Literature References

Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery: J.M. Bailey, et al.; Anesthesiology 81, 616 (1994), Abstract;
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor: D. Wilhelm, et al.; J. Cardiovasc. Pharmacol. 20, 705 (1992), Abstract;
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991), Abstract;
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels: S.H. Lindgren, et al.; Acta Physiol. Scand. 140, 209 (1990), Abstract;
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989), Abstract;
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol. 29, 506 (1986), Abstract;

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