Replaces Prod. #: BML-PD152
Selective inhibitor of phosphodiesterase 3 (PDE3, IC50=0.3µM).
Product Details
| Alternative Name: | 1,6-Dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile |
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| Formula: | C12H9N3O |
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| MW: | 211.2 |
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| CAS: | 78415-72-2 |
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| MI: | 14: 6197 |
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| RTECS: | DW1762000 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to light red solid. |
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| Solubility: | Soluble in DMSO (20mg/ml) or warm 100% ethanol (3mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery: J.M. Bailey, et al.; Anesthesiology
81, 616 (1994),
Abstract;
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor: D. Wilhelm, et al.; J. Cardiovasc. Pharmacol.
20, 705 (1992),
Abstract;
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol.
42, 679 (1991),
Abstract;
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels: S.H. Lindgren, et al.; Acta Physiol. Scand.
140, 209 (1990),
Abstract;
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol.
38, 3331 (1989),
Abstract;
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol.
29, 506 (1986),
Abstract;
