Replaces Prod. #: BML-PR105
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Details
| Alternative Name: | Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione |
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| Formula: | C10H12O4 |
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| MW: | 196.2 |
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| CAS: | 56-25-7 |
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| MI: | 14: 1752 |
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| Purity: | ≥98% (GC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MAP kinases associate with high molecular weight multiproteincomplexes: C.J. Bequette, et al.; J. Exp. Bot.
69, 643 (2018),
Abstract;
Full Text
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep.
32, 513 (2014),
Abstract;
Full Text
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol.
46, 1435 (1993),
Abstract;
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li & J.E. Casida; PNAS
89, 11867 (1992),
Abstract;
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol.
33, 706 (1988),
Abstract;
