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Cantharidin

PP2A inhibitor
 
ALX-270-063-M025 25 mg 62.00 USD
 
ALX-270-063-M100 100 mg 192.00 USD
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Replaces Prod. #: BML-PR105

Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).

Product Specification

Alternative Name:Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
 
Formula:C10H12O4
 
MW:196.2
 
CAS:56-25-7
 
MI:14: 1752
 
Purity:≥98% (GC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
ALX-270-063
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ALX-270-063

Product Literature References

PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep. 32, 513 (2014), Abstract; Full Text
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993), Abstract;
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li & J.E. Casida; PNAS 89, 11867 (1992), Abstract;
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988), Abstract;

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