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Bisindolylmaleimide VIII . acetate

PKC inhibitor
 
ALX-270-056-M001 1 mg 48.00 USD
 
ALX-270-056-M005 5 mg 175.00 USD
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Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Product Specification

Alternative Name:Ro 31-7549 . acetate
 
Formula:C24H22N4O2 . CH3COOH
 
MW:398.5 . 60.1
 
CAS:138516-31-1
 
Purity:≥98%
 
Appearance:Red powder.
 
Solubility:Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
ALX-270-056
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ALX-270-056

Product Literature References

Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004), Abstract; Full Text
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002), Abstract; Full Text
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999), Abstract;

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