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Aristolochic acid

Reversible noncompetitive PLA2 inhibitor.
 
ALX-270-047-M025 25 mg 56.00 USD
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Replaces Prod. #: BML-EI175

Phospholipase A2 (PLA2) inhibitor active against the enzymes found in many snake venoms as well as those of human platelets and synovial fluids. Inhibits ionophore-stimulated PLA2 activity in human neutrophils. Has been shown to be nephropathic and carcinogenic.

Product Specification

Alternative Name:8-Methoxy-6-nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid, 6-Nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid
 
Formula:C17H11NO7 (Aristolochic acid I) and C16H9NO6 (Aristolochic acid II)
 
MW:341.3 (Aristolochic acid I) and 311.3 (Aristolochic acid II)
 
Source:Isolated from Aristolochia.
 
CAS:313-67-7 (Aristolochic acid I), 475-80-9 (Aristolochic acid II), 67123-64-2 (mixture)
 
MI:14: 786
 
RTECS:CF3325000
 
Purity:≥97% (~1:1 mixture of aristolochic acids I (A) and II (B))
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO or 100% ethanol. Sparingly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-270-047 structure II
Aristolochic acid II
ALX-270-047 structure I
Aristolochic acid I
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ALX-270-047 structure II ALX-270-047 structure I

Product Literature References

Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process: J.J. Reina-Pinto, et al.; Plant Cell 21, 1252 (2009), Abstract; Full Text
Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells: Y.H. Hsin, et al.; Apoptosis 11, 2167 (2006), Abstract;
Aristolochic acid and ’Chinese herbs nephropathy’: a review of the evidence to date: J.P. Cosyns; Drug Saf. 26, 33 (2003), Review, Abstract;
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy: H.H. Schmeiser, et al.; Cancer Res. 56, 2025 (1996), Abstract;
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993), Abstract;
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils: J.D. Winkler, et al.; Biochem. Pharmacol. 44, 2055 (1992), Abstract;
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1126, 319 (1992), Abstract;
Suramin alters phosphoinositide synthesis and inhibits growth factor receptor binding in HT-29 cells: R. Kopp & A. Pfeiffer; Cancer Res. 50, 6490 (1990), Abstract;
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1001, 3 (1989), Abstract;
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid: B.S. Vishwanath, et al.; Inflammation 12, 549 (1988), Abstract;
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid: B.S. Vishwanath, et al.; Toxicon 25, 501 (1987), Abstract;
Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities: B.S. Vishwanath & T.V. Gowda; Toxicon 25, 929 (1987), Abstract;
Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study: B.S. Vishwanath, et al.; Toxicon 25, 939 (1987), Abstract;

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