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3-Aminobenzamide

PARP inhibitor
 
ALX-270-044-G001 1 g 59.00 USD
 
ALX-270-044-G005 5 g 211.00 USD
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Replaces Prod. #: BML-G400

Inhibits endogenous poly-ADP-ribosyltransferases often present in membrane preparations with minimal effect of bacterial toxin mediated ADP-ribosylation. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells. Protects cells from oxygen radical and nitric oxide toxicity. Inhibits stress-induced apoptosis.

Product Specification

Alternative Name:3-AB
 
Formula:C7H8N2O
 
MW:136.2
 
CAS:3544-24-9
 
RTECS:CU8992000
 
Purity:≥97% (GC)
 
Appearance:White to tan powder.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-270-044
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ALX-270-044

Product Literature References

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Cell culture, Abstract; Full Text
Genistein induces apoptotic cell death associated with inhibition of the NF-κB pathway in adult T-cell leukemia cells: M. Yamasaki, et al.; Cell. Biol. Int. 37, 742 (2013), Abstract;
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract;
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents: A. Pogrebniak, et al.; Eur. J. Med. Res. 11, 313 (2006), Abstract;
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996), Abstract;
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995), Abstract;
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995), Abstract;
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994), Abstract;
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994), Abstract;
Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis: C. Nosseri, et al.; Exp. Cell Res. 212, 367 (1994), Abstract;
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC 179, 1225 (1991), Abstract;
ADP-Ribose Transfer Reactions, Mechanisms and Biological Significance (M.K. Jacobsen & E.L. Jacobsen, eds.): C.J. Skidmore, et al.; Springer Verlag, New York 109 (1989),

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The PARP Family & ADP Ribosylation
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