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AMT . hydrochloride

iNOS inhibitor
ALX-270-033-M010 10 mg 107.00 USD
ALX-270-033-M050 50 mg 398.00 USD
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Potent and selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II).

Product Specification

Alternative Name:2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine . HCl
Formula:C5H10N2S . HCl
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water or 100% ethanol.
Long Term Storage:+4°C
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Product Literature References

Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells: S.O. Cho, et al.; Dig. Dis. Sci. 55, 988 (2010), Abstract;
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats: P. Clement, et al.; Neuroscience 135, 347 (2005), Abstract;
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy: B.T. Alexander, et al.; Hypertension 39, 586 (2002), Abstract;
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract; Full Text
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats: A.M. Briones, et al.; Br. J. Pharmacol. 126, 111 (1999), Abstract;
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition: M.A. Rudd, et al.; Am. J. Physiol. 277, H732 (1999), Abstract;
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus: R.L. Rairigh, et al.; J. Clin. Invest. 101, 15 (1998), Abstract;
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors: W.R. Tracey, et al.; Can. J. Physiol. Pharmacol. 73, 665 (1995), Abstract;
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol. 47, 831 (1995), Abstract;

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