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S-Ethyl-ITU . hydrobromide

NOS inhibitor
 
ALX-270-025-M250 250 mg 41.00 USD
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Replaces Prod. #: BML-CN260

Potent cell-permeable inhibitor of nitric oxide synthase (NOS; IC50=82 nM in J774 cells). Ki’s using all human iNOS, eNOS and nNOS (19, 39 and 29 nM respectively) indicate doubtful selectivity.

Product Specification

Alternative Name:S-Ethylisothiourea . HBr, 2-Ethyl-2-thiopseudourea . HBr
 
Formula:C3H9NSBr
 
MW:185.1
 
CAS:1071-37-0
 
RTECS:UM6825000
 
Purity:≥97%
 
Appearance:White powder.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Hygroscopic.
 
ALX-270-025
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ALX-270-025

Product Literature References

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity: G.J. Southan, et al.; Br. J. Pharmacol. 114, 510 (1995), Abstract;
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol. 47, 831 (1995), Abstract;
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas: E.P. Garvey, et al.; J. Biol. Chem. 269, 26669 (1994), Abstract; Full Text

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