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3-Bromo-7-nitroindazole

NOS inhibitor
 
ALX-270-009-M005 5 mg 16.00 USD
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Replaces Prod. #: BML-CN252

Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole (Prod. No. ALX-270-004).

Product Specification

Formula:C7H4BrN3O2
 
MW:242.0
 
CAS:74209-34-0
 
Purity:≥98%
 
Appearance:Yellowish solid.
 
Solubility:Soluble in DMSO (50mg/ml), methanol or 100% ethanol; also soluble in water containing 10% DMSO or in a 50:50 mixture of water:DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
270-009
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270-009

Product Literature References

Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56 (2006), Abstract;
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry 40, 13448 (2001), Abstract;
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res. 870, 80 (2000), Abstract;
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience 78, 393 (1997), Abstract;
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol. 324, 11 (1997), Abstract;
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci. 57, PL131 (1995), Abstract;

Related Products

7-Nitroindazole 

NOS inhibitor
2942-42-9, ≥98% (HPLC) | Print as PDF
 
ALX-270-004-M100 100 mg 35.00 USD
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