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Q-VD-OPH

Caspase inhibitor
 
ALX-260-159-M003 3 mg 963.00 USD
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Selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Protects neurotoxin-insulted neurons from apoptotic death. Displays minimal in vivo toxicity. To reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.

Product Specification

Alternative Name:pan-Caspase inhibitor (fluoromethylketone), N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone
 
Formula:C26H25F2N3O6
 
MW:513.8
 
Purity:≥90% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10mM).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light. Keep under inert gas. Hygroscopic.
 

Product Literature References

Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells: R. Ryan, et al.; BMC Microbiol. 11, 237 (2011), Application(s): WB of human dendritic cells, Abstract; Full Text
Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia: K. Patil & S.C. Sharma; Neuroreport 15, 981 (2004), Abstract;
Caspase inhibition switches doxorubicin-induced apoptosis to senescence: A. Rebbaa, et al.; Oncogene 22, 2805 (2003), Abstract;
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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