Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
Product Details
Alternative Name: | Caspase-1 inhibitor (fluoromethylketone) |
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Sequence: | Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone |
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MW: | 630.7 |
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Source: | Synthetic. |
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Formulation: | Liquid. In DMSO. |
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Purity: | ≥99% (HPLC) |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Technical Info/Product Notes: | We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress: M.B. Wachte, et al.; Life Sci. Alliance
6, e202201494 (2023),
Abstract;
Inflammasome-Driven Interleukin-1α andInterleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity: X. Jiang, et al.; JACC Basic Transl. Sci.
4, 304 (2019),
Abstract;
Full Text
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation: C. Zhang, et al.; J. Clin. Invest.
128, 5399 (2018),
Abstract;
Full Text
Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol.
8, 1238 (2017),
Abstract;
Full Text
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages: C. Smalley, et al.; PLoS One
11, e0157231 (2016),
Application(s): Caspase-1 inhibition,
Abstract;
Full Text
Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile: C. A. Cowardin, et al.; MBio.
6, e02386-14 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction: L. Mortimer, et al.; PLoS Pathog.
11, e1004887 (2015),
Abstract;
Full Text