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Z-YVAD-FMK (Ready-to-Use)

Inhibitor of caspase-1 and -4
 
ALX-260-154-R100 100 µl 2mM 189.00 USD
 
ALX-260-154-R020 20 µl 10mM 189.00 USD
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Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.

Product Specification

Alternative Name:Caspase-1 inhibitor (fluoromethylketone)
 
Sequence:Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
 
MW:630.7
 
Source:Synthetic.
 
Formulation:Liquid. In DMSO.
 
Purity:≥99% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol. 8, 1238 (2017), Abstract; Full Text
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages: C. Smalley, et al.; PLoS One 11, e0157231 (2016), Application(s): Caspase-1 inhibition, Abstract; Full Text
Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile: C. A. Cowardin, et al.; MBio. 6, e02386-14 (2015), Application(s): Cell Culture, Abstract; Full Text

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RELATED PRODUCTS

By target:
Caspase
Caspase-1
Caspase-4
By biological activity:
Caspase Inhibitor
Caspase-1 Inhibitor
Caspase-4 Inhibitor
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For Research Use Only. Not for use in diagnostic procedures.
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