Irreversible, cell permeable inhibitor of caspase-9.
Product Details
Alternative Name: | Caspase-9 inhibitor (fluoromethylketone) |
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Sequence: | Z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethylketone |
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MW: | 690.7 |
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Formulation: | Liquid. In DMSO. |
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Purity: | ≥98% (HPLC) |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Technical Info/Product Notes: | We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6: S. Schüll, et al.; Cell Death Dis.
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Application(s): Cell Culture,
Abstract;
Full Text
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression: F. Zhong, et al.; Oncol. Lett.
10, 1416 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem.
272, 17907 (1997),
Abstract;