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Z-LEHD-FMK (Ready-to-Use)

Caspase-9 inhibitor
 
ALX-260-145-R100 100 µl 2mM 185.00 USD
 
ALX-260-145-R020 20 µl 10mM 185.00 USD
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Irreversible, cell permeable inhibitor of caspase-9.

Product Specification

Alternative Name:Caspase-9 inhibitor (fluoromethylketone)
 
Sequence:Z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
 
MW:690.7
 
Formulation:Liquid. In DMSO.
 
Purity:≥98% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6: S. Schüll, et al.; Cell Death Dis. 6, e1691 (2015), Application(s): Cell Culture, Abstract; Full Text
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression: F. Zhong, et al.; Oncol. Lett. (2015), Application(s): Cell Culture, Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

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