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Z-IETD-FMK (Ready-to-Use)

Caspase and granzyme inhibitor
 
ALX-260-144-R100 100 µl 2mM 189.00 USD
 
ALX-260-144-R020 20 µl 10mM 189.00 USD
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Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. The inhibitor is designed as a methyl ester to facilitate cell permeability. 

Product Specification

Alternative Name:Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone)
 
Sequence:Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
 
MW:654.0
 
Formulation:Liquid. In DMSO.
 
Purity:≥99% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol. 8, 1238 (2017), Abstract; Full Text
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src: Y. Diao, et al.; Cancer Lett. 379, 12 (2016), Application(s): Cell culture, Abstract;
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB: M. Oliver Metzig, et al.; Oncogene 35, 3399 (2016), Application(s): Cell culture , Abstract;
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6: S. Schüll, et al.; Cell Death Dis. 6, e1691 (2015), Application(s): Cell Culture, Abstract; Full Text
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death: A.L. Mahul-Mellier, et al.; Cell Death Differ. 22, 2107 (2015), Application(s): Cell Culture, Abstract;
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression: F. Zhong, et al.; Oncol. Lett. (2015), Application(s): Cell Culture, Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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