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Z-IETD-FMK (Ready-to-Use)

Caspase and granzyme inhibitor
 
ALX-260-144-R100 100 µl 2mM 185.00 USD
 
ALX-260-144-R020 20 µl 10mM 185.00 USD
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Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. The inhibitor is designed as a methyl ester to facilitate cell permeability. 

Product Specification

Alternative Name:Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone)
 
Sequence:Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
 
MW:654.0
 
Formulation:Liquid. In DMSO.
 
Purity:≥99% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src: Y. Diao, et al.; Cancer Lett. 379, 12 (2016), Application(s): Cell culture, Abstract;
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB: M. Oliver Metzig, et al.; Oncogene 35, 3399 (2016), Application(s): Cell culture , Abstract;
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6: S. Schüll, et al.; Cell Death Dis. 6, e1691 (2015), Application(s): Cell Culture, Abstract; Full Text
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death: A.L. Mahul-Mellier, et al.; Cell Death Differ. 22, 2107 (2015), Application(s): Cell Culture, Abstract;
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression: F. Zhong, et al.; Oncol. Lett. (2015), Application(s): Cell Culture, Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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