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N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde

Cathepsin-L inhibitor
 
ALX-260-133-M001 1 mg 138.00 USD
 
ALX-260-133-M005 5 mg 459.00 USD
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Potent, selective and reversible inhibitor of human cathepsin L (IC50=1.9nM). Inhibits release of Ca2+ and hydroxyproline from bone in vitro.

Product Specification

Alternative Name:N-(1Naphthalenylsulfonyl)- IW-CHO
 
Formula:C27H29N3O4S
 
MW:491.6
 
CAS:161709-56-4
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or ethyl acetate (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

The protease cathepsin L regulates Th17 cell differentiation: L. Hou, et al.; J. Autoimmun. 65, 56 (2015), Application(s): Cell Culture, Abstract;
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice: T. Wartmann, et al.; Gastroenterology 138, 726 (2010), Abstract; Full Text
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption: T. Yasuma, et al.; J. Med. Chem. 41, 4301 (1998), Abstract;

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