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Z-Phe-Arg-AFC . trifluoroacetate

Cathepsin-L substrate
 
ALX-260-129-M005 5 mg 61.00 USD
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Fluorogenic cathepsin L substrate.

Product Specification

Alternative Name:Z-FR-AFC . TFA
 
Sequence:Z-Phe-Arg-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
 
Formula:C33H33O6N6F3 . C2HF3O2
 
MW:666.7 . 114.0
 
Purity:≥98%
 
Appearance:White lyophilized powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice: V.A. Fajardo, et al.; PLoS One 12, e0173708 (2017), Abstract; Full Text
Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin: T.L. Campbell, et al.; Data Brief 7, 786 (2016), Application(s): Measured cathepsin activity in mixed gastrocnemius homogenates, Abstract;
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype: V.A. Fajardo, et al.; Dis. Model Mech. 8, 999 (2015), Application(s): Fluorescence, Abstract; Full Text
Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group: J.R. Tchoupe, et al.; Biochim. Biophys. Acta 1076, 149 (1991), Abstract;

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