Fluorogenic substrate for caspase-1, -4, -5 and -14.
Product Details
| Alternative Name: | Caspase-1 substrate (fluorogenic), Caspase-5 substrate (fluorogenic) |
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| Sequence: | Ac-Trp-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin) |
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| Formula: | C38H37F3N8O11 |
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| MW: | 838.8 |
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| Peptide Content: | 70-90% |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to yellow powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solution in DMSO is stable for 6-8 months when stored at -20°C. |
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| Handling: | Keep cool and dry. |
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| Technical Info/Product Notes: | AFC has an excitation maximum of 400nm and an emission maximum of 505nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold: B.B. Verdugo, et al.; J. Biol. Chem.
298, 101931 (2022),
Abstract;
Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome: R.V.H. De Carvalho, et al.; Cell Rep.
26, 429 (2019),
Abstract;
Noninvasive evaluation of the chronic influence of local air velocity from an air conditioner using salivary cortisol and skin caspase-14 as biomarkers of psychosomatic and environmental stress: M. Yamaguchi, et al.; J. Int. Med. Res.
40, 1429 (2012),
Abstract;
