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Ac-LEHD-AFC

Caspase-9 substrate
 
ALX-260-116-M005 5 mg 194.00 USD
 
ALX-260-116-M010 10 mg 338.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P445

Fluorogenic substrate for caspase-9.

Product Specification

Alternative Name:Caspase-9 substrate (fluorogenic)
 
Sequence:Ac-Leu-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
 
Formula:C33H38F3N7O11
 
MW:765.7
 
CAS:210345-03-2
 
Formulation:Lyophilized.
 
Purity:≥96% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Technical Info/Product Notes:AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
 

Product Literature References

Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells: Y. Pang, et al.; Exp. Cell Res. 16, 30161 (2016), Application(s): Fluorometric assay for caspase-9 activity, Abstract;
Mechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation: N. Yadav, et al.; Free Radic. Biol. Med. 90, 261 (2016), Application(s): Quantification of apoptosis and caspase activity measurement, Abstract;
Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents: N. Yadav, et al.; Cell Death Dis. 5, e1969 (2015), Application(s): Cell culture, Fluorescence, Abstract;
Redox regulation of metabolic and signaling pathways by thioredoxin and GLUTAREDOXIn in nos-3 overexpressing hepatoblastoma cells: R. González, et al.; Redox Biol. 6, 122 (2015), Application(s): Cell Culture, Fluorescence, Abstract;

General Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

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