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Ac-VEID-AFC

Caspase-6 inhibitor
 
ALX-260-111-M005 5 mg 175.00 USD
 
ALX-260-111-M010 10 mg 275.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P439

Fluorogenic substrate for caspase-6 (Km=30μM; Kcat/Km=168000 M-1sec-1) and related cysteine proteases. Sequence is based on lamin A site of cleavage.

Product Specification

Alternative Name:Caspase-6 substrate (fluorogenic)
 
Sequence:Ac-Val-Glu-Ile-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
 
Formula:C32H40F3N5011
 
MW:727.7
 
Purity:≥98% (HPLC)
 
Solubility:Soluble in DMSO or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Technical Info/Product Notes:AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
 

Product Literature References

Organ specific alteration in caspase expression and STK3 proteolysis during the aging process: M. Lessard-Beaudoin, et al.; Neurobiol. Aging 47, 50 (2016), Application(s): Caspase activity assays, Abstract; Full Text

General Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula, et al.; J. Biol. Chem. 271, 27099 (1996), Abstract;

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