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Ac-YVAD-AFC

Substrate for caspase-1 and -4
 
ALX-260-108-M005 5 mg 115.00 USD
 
ALX-260-108-M010 10 mg 216.00 USD
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Fluorogenic substrate for caspase-1 and -4.

Product Specification

Alternative Name:Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic)
 
Sequence:Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
 
Formula:C33H36F3N5O10
 
MW:719.7
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
 
Handling:Keep cool and dry.
 
Technical Info/Product Notes:AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
 

Product Literature References

Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP: M. Marcelli, et al.; Cancer Res. 58, 76 (1998), Abstract;

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