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Biotinyl-VAD(OMe)-FMK

Caspase inhibitor
 
ALX-260-098-M001 1 mg 522.00 USD
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Irreversible, cell permeable broad-spectrum caspase inhibitor.

Product Specification

Alternative Name:Caspase family inhibitor (fluoromethylketone)
 
Sequence:Biotinyl-Ahx-Val-Ala-Asp(OMe)-fluoromethylketone
 
Formula:C30H49FN6O8S
 
MW:672.8
 
Purity:≥90% (TLC)
 
Appearance:Off-white to brown powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C. The stock solution is stable at -20°C for 6-8 months.
 
Handling:Keep cool and dry.
 
Protocol:Prepare a 10mM stock solution of the caspase inhibitor in high quality DMSO. Add 2μl of this stock solution to 1ml of culture medium containing cells to give 20μM final concentration. Effective final concentrations are estimated to be 5-20μM. If a particular caspase inhibitor is applied at higher concentrations specificity for an individual caspase or even for the caspase family (>100μM) might be compromised. DMSO concentration above 0.2% may cause cellular toxicity thus masking the effect of the caspase inhibitor. For in vivo experiments extending for 12 to 48 hours, fresh inhibitor may have to be added (injected) due to inactivation by reaction with cysteine protease.
 

Product Literature References

Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes: J. Li, et al.; J. Biol. Chem. 274, 17325 (1999), Abstract; Full Text

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