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MG-115

Proteasome inhibitor
 
ALX-260-091-M001 1 mg 95.00 USD
 
ALX-260-091-M005 5 mg 158.00 USD
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Replaces Prod. #: BML-ZW8445

Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.

Product Specification

Alternative Name:Z-LL-Nva-CHO, Z-Leu-Leu-Nva-CHO
 
Sequence:Z-Leu-Leu-Nva-CHO
 
Formula:C25H39N3O5
 
MW:461.6
 
CAS:133407-86-0
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9: J. Won Yoon, et al.; DNA Repair (Amst.) 34, 9 (2015), Application(s): Western Blot, Abstract;
Ras is involved in the negative control of autophagy through the class I PI3-kinase: S. Furuta, et al.; Oncogene 23, 3898 (2004), Abstract;
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression: L. Salmena, et al.; Biochem. Pharmacol. 61, 795 (2001), Abstract;
Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death: J.N. Keller & W.R. Markesbery; J. Neurosci. Res. 61, 436 (2000), Abstract;
p53-dependent induction of apoptosis by proteasome inhibitors: U.G. Lopes, et al.; J. Biol. Chem. 272, 12893 (1997), Abstract; Full Text
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae: D.H. Lee & A.L. Goldberg; J. Biol. Chem. 271, 27280 (1996), Abstract; Full Text
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell 78, 761 (1994), Abstract;
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B: V.J. Palombella, et al.; Cell 78, 773 (1994), Abstract;
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex: A. Vinitsky, et al.; Biochemistry 31, 9421 (1992), Abstract;

General Literature References

The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12h cells: Y. Saito, et al.; Neurosci. Lett. 120, 1 (1990), Abstract;

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