Potent and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the 26S proteasome (MCP; multicatalytic proteinase complex). Does not inhibit the peptidylglutamyl-peptide hydrolyzing activity of the MPC.
Product Details
| Alternative Name: | Z-LLF-CHO, Z-Leu-Leu-Phe-CHO |
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| Sequence: | Z-Leu-Leu-Phe-CHO |
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| Formula: | C29H39N3O5 |
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| MW: | 509.7 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis: S.L. Schauer, et al.; J. Immunol.
160, 4398 (1998),
Abstract;
Full Text
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes): M. Orlowski, et al.; Biochemistry
36, 13946 (1997),
Abstract;
Full Text
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids: M. Orlowski, et al.; Biochemistry
32, 1563 (1993),
Abstract;
