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Proteasome inhibitor II (aldehyde)

 
ALX-260-090-M001 1 mg 60.00 USD
 
ALX-260-090-M005 5 mg 190.00 USD
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Potent and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the 26S proteasome (MCP; multicatalytic proteinase complex). Does not inhibit the peptidylglutamyl-peptide hydrolyzing activity of the MPC.

Product Specification

Alternative Name:Z-LLF-CHO, Z-Leu-Leu-Phe-CHO
 
Sequence:Z-Leu-Leu-Phe-CHO
 
Formula:C29H39N3O5
 
MW:509.7
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis: S.L. Schauer, et al.; J. Immunol. 160, 4398 (1998), Abstract; Full Text
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes): M. Orlowski, et al.; Biochemistry 36, 13946 (1997), Abstract; Full Text
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids: M. Orlowski, et al.; Biochemistry 32, 1563 (1993), Abstract;

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