Proteasome inhibitor I (aldehyde)



ALX-260-089-M001	1 mg	26.00 USD

ALX-260-089-M005	5 mg	104.00 USD

Replaces Prod. #: BML-ZW8410

Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid (Prod. No. ALX-350-003) through inhibition of IκBα degradation.

Product Specification

Alternative Name:	Z-IE(OtBu)AL-CHO, Z-Ile-Glu(OtBu)-Ala-Leu-CHO, PSI

Formula:	C₃₂H₅₀N₄O₈

MW:	618.8

Purity:	≥95% (TLC)

Appearance:	White powder.

Sequence:	Z-Ile-Glu(OtBu)-Ala-Leu-CHO

Solubility:	Soluble in 100% ethanol (30mg/ml), DMSO (30mg/ml) or methanol (50mg/ml).

Long Term Storage:	-20°C

Product Literature References

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B: J.M. Griscavage, et al.; PNAS 93, 3308 (1996), Abstract; Full Text

Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway: S. Mori, et al.; J. Biol. Chem. 270, 29447 (1995), Abstract; Full Text

A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin- protein conjugates in a neuronal cell: M.E. Figueiredo-Pereira, et al.; J. Neurochem. 63, 1578 (1994), Abstract;

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B: E.B. Traenckner, et al.; EMBO J. 13, 5433 (1994), Abstract;